Genetic and Neurodevelopmental Influences in Autistic Disorder

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Genetic and neurodevelopmental influences in autistic disorder.

OBJECTIVE In the past, autism was considered to be largely psychogenic. However, research in the last 2 decades indicates that autism is largely caused by genetic factors that lead to abnormal brain development. This article reviews research into the genetic and neurodevelopmental factors underlying autism. METHODS We review the findings from genetic and brain-imaging studies of autism over t...

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Conduct disorder (CD) is a moderately heritable psychiatric disorder of childhood and adolescence characterized by aggression toward people and animals, destruction of property, deceitfulness or theft, and serious violation of rules. Genome-wide scans using linkage and association methods have identified a number of suggestive genomic regions that are pending replication. A small number of cand...

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Autistic disorder, an extremely disabling syndrome with onset in early childhood, is associated with multiple comorbid conditions. Although autistic disorder is heterogeneous in its manifestations, there is a subgroup of individuals with autistic disorder who display movements that appear to be unique for the disorders. Hand flapping and a variety of movements termed stereotypies may be pathogn...

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ژورنال

عنوان ژورنال: The Canadian Journal of Psychiatry

سال: 2003

ISSN: 0706-7437,1497-0015

DOI: 10.1177/070674370304800804